Mohamed Naguib - His Work and Influence
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ISAP 3rd Annual Mohamed Naguib Lecture October 13, 2023
General Introduction on the Role of Pro-resolving Mediators (SPMs)
Presented by Charles N. Serhan, PhD, DSc
Generous support provided by Senzime Corporation
Dr. Charles Serhan, PhD, DSc, will present the 2023 Mohamed Naguib Lecture on the topic of: General Introduction on the Role of Pro-resolving Mediators (SPMs).
Professor Charles N. Serhan holds the Gelman Professorship Harvard Medical School, is Director of the Center for Experimental Therapeutics and Reperfusion Injury and Professor of Oral Medicine, Infection and Immunity, Harvard University, Boston, MA.
Research in Dr. Serhan’s laboratory focuses on structural elucidation of bioactive small molecules that activate the resolution of acute inflammation. The overall mission is “To identify novel mediators, pathways, and cellular targets critical in promoting resolution of inflammation and reperfusion tissue injury and their relation to human disease.”
His studies currently focus on structural elucidation of novel molecules and pathways that serve as pro-resolving and/or endogenous anti-inflammatory chemical signals. He elucidated several new families of lipid-derived, local-acting chemical mediators, coined the Resolvins and Protectins, and most recently Maresins, that stimulate resolution of inflammatory responses. He also designed novel therapeutic approaches using these structures as biotemplates. New therapeutic approaches built with the knowledge of these signaling pathways could be more potent, selective and better tolerated since they are based on structures naturally evolved in these processes. Several of these new designer therapeutics have already been shown to be effective in human disease.
About Dr. Mohamed Naguib
International Society of Anaesthetic Pharmacology (ISAP), established the Mohamed Naguib Lecture to honor the late Dr. Mohamed Naguib. Dr. Naguib had a distinguished career in the field of anesthesiology and was a long supporter of ISAP, serving as President of the society. He made significant contributions to the scientific foundation and clinical applications of neuromuscular monitoring. This named lecture is given at each ISAP Annual Meeting.
ISAP has established a fund to endow the Mohamed Naguib Lecture and donations may be made at isaponline.org.ISAP has established a fund to endow the Mohamed Naguib Lecture and donations may be made at isaponline.org.
In the world of clinical pharmacology, Dr. Naguib was a renaissance man. As a man of many talents, his influential work has provided direction in many spheres of investigation and discovery. He made significant contributions to the scientific foundation and clinical applications of neuromuscular monitoring. He formed and led a coalition of thought leaders to prepare and disseminate expert consensus guidelines on neuromuscular monitoring. He had substantial interest in the mechanisms of and treatment for neuropathic pain. He led a laboratory that created molecules to treat neuropathic pain. At the time of his passing, he was a principal investigator on NIH funded multi-center observational study focused on the discovery and validation of a biomarker signature for chemotherapy induced peripheral neuropathic pain. He was the co-founder of a company that is developing a novel therapy for neuropathic pain and Alzheimer’s disease based on his research on the mechanisms of neuroinflammation. For each of these activities, he created a wake of opportunities for many that continue to have a vibrant and productive future. He was a prolific writer. He was the principal author or co-author of 130 peer-reviewed journal articles, 25 book chapters (including the premier Miller’s Textbook of Anesthesia) and 150 abstracts.
Dr. Naguib was graduated from the Cairo University, College of Medicine, in 1976 and finished his anesthesia residency in 1981. He served as a Post-Doctoral Research Fellow in the Department of Anesthesiology, University of California, San Diego, California. In 1992 he joined the Department of Anesthesia at the College of Medicine, King Saud University. In 1998 he joined the University of Texas MD Anderson Cancer Center in Houston. His last position was the 2010 appointed as Professor of Anesthesiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.